activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
| PAG Title | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| PAG ID | WAG000424 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Interaction of T cell receptor with specific antigen in the context of MHC II activates a sigl transduction pathway that leads to T cell activation. In the T cell receptor sigling pathway, the src family kises Lck and Fyn are activated to phosphorylate proteins in the T cell receptor complex which recruit and activate the ZAP70 kise. The activation of ZAP70 phosphorylates downstream targets that activate MAP kise pathways and cause T cell activation. The CD45 phosphorylase also plays a role in T cell receptor sigling, dephosphorylated Lck and Fyn to activate them. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,612 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000424 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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